DNA methylation

[liam]

Is DNA methylation the only epigenetic modification that can happen to DNA?

[noah]

DNA methylation itself can be further broken down also. Dependent upon the histone/amino acid methylated, the function of the methylation is different.

[liam]

@noah
Hi Thanks for your reply
if you don’t mind can gives any example ?

[noah]

Sure why not for example H3K4Me tends to result in upregulation of the gene in question, while H3K27Me tends to switch off transcription of that gene.

[johnbelley]

Phosphorylation and ubiquitinylation are also there, not as much as the other two though. Most of the time ubiquitin is used to mark proteins for degradation

[liam]

@noah
Thank you so much

@johnbelley
Does it induce some histone modifications ?

[johnbelley]

Ofcourse it can induce some histone modifications.And also adding a SUMO group, but I’m not sure if that’s an epigenetic modification or not, I don’t think it is.

[alex]

You could also have acetylation and de-acetylation. Although not happening on the DNA (rather histone proteins) but they are also epigenetic modifications.

[Author]

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